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Welcome to Maybridge

The Maybridge portfolio offers a comprehensive range of chemistry products and services tailored to the drug discovery and biotechnology sector. For over 50 years, Maybridge has been at the forefront of innovative heterocyclic building block and screening compound design, fuelled by the desire to access novel molecules of pharmaceutical interest.

The Maybridge portfolio is driven by a keen understanding of the needs of the medicinal chemist and is designed to expedite the drug discovery process.

A recent article in Drug Discovery World co-authored by Dr Edward Zartler, Dr Chris Swain and Simon Pearce of Maybridge focused on the evolution of fragment-based lead discovery and how recent research has influenced fragment library design. To download the complete article as a pdf please Click Here
Thermo Fisher Scientific selected by leading dutch biotech company to supply Maybridge Fragment Library for key research

Hit-to-Lead Building Blocks The core of the Maybridge building block collection, these pharmacophorically rich intermediates are specifically designed for medicinal chemistry, allowing logical SAR development and Hit-to-Lead optimization. Many will be of particular interest as “privileged structures” while others bearing solubilizing moieties add to the pharmacokinetic profile of drug molecules.
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  • How to Search for Building Blocks (pdf)
  • Screening A highly diverse set of over 53,000 hit-like and lead-like molecules widely acknowledged as a critical tool in screening campaigns.
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  • Fragment Libraries 30,000 small compounds (mw<300) taken from the complete Maybridge collection for use in fragment screening to further accelerate the identification of lead compounds.
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  • Ro3 2500 Diversity Fragment Library The Maybridge Ro3 Diversity Library is a diverse selection of 2500 products from the complete Fragment Collection. It is fully Ro3 compliant with assured quality of >= 95% purity and assured solubility.
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  • HitFinder 14,400 compounds selected to represent the overall diversity of the screening collection available pre-plated at 1µmol in 96-well plates or .25µmol in 384-well plates.
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  • HitDiscover The entire Maybridge screening collection of over 53,000 compounds is available off-the-shelf, pre-plated as 1umol dry films in 96 well plate format. Exceptional diversity and outstanding value!
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  • Global HitFinder The ultimate diversity screening library. Our new offering takes away the need to choose between different libraries by providing the ultimate coverage of drug-like chemical space with a single library. Building on 50 years of expertise in designing industry leading screening libraries the Maybridge Global HitFinder is derived from a rigorous analysis of more than 5 million commercially available screening compounds and represents the characteristics of all the different commercial libraries. Please contact maybridge.sales@thermofisher.com to request access to the SD file.
    Chiral Resolution Maybridge Chiral Resolution Screening and Purification Kits – Using these ready-to-use kits can reduce time to identify the best separation conditions to just one day.
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  • Thermo Fisher Scientific Inc